Chromatin signaling in transcription and erythropoiesis

来源 :The 2nd International Symposium on Erythrocyte Biology(2016第 | 被引量 : 0次 | 上传用户:skychi
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The modulation of chromatin structure is a key step in transcription regulation in mammalian cells that eventually determines lineage commitment and differentiation,but the epigenetic regulators that modulate and coordinate these changes are largely unknown.
其他文献
会议
会议
会议
My lab is interested in studying the epigenetic factors which control erythropoiesis.The key regulators,such as antagonistic regulators GATA-1 and PU.1,are responsible for the commitment and different
会议
会议
The KLF1 transcription factor regulates nearly all aspects of erythroid differentiation including heme synthesis and globin regulation.Previously,in collaborative studies with Dr.James Bieker (New Yor
会议
Reactivation of γ-globin expression has been shown to ameliorate disease phenotypes associated with mutations in the adult β-globin gene,including sickle cell disease.Previous studies have shown that
会议
Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin.Pomalidomide,a third-generation immunomodulatory drug,was proposed to induce fetal hemoglobin productio
会议
Iron overload results in significant morbidity and mortality in β-thalassemic patients.Insufficient hepcidin is implicated in parenchymal iron overload in β-thalassemia and approaches to increase hepc
Erythropoietin (Epo) plays a critical role in the regulation of red cell mass (RCM) according to tissue oxygen levels.Hypoxia inducible factor-2 (HIF-2) is known to be a master regulator for Epo expre
会议