【摘 要】
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Objective To investigate the effects of O-carboxymethyl chitosan (O-CMC) multi-hemostatic Sponge on the immobilization of thrombin.Methods The formulation o
【机 构】
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Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command, Hubei Wuhan, 430070, C
【出 处】
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2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
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Objective To investigate the effects of O-carboxymethyl chitosan (O-CMC) multi-hemostatic Sponge on the immobilization of thrombin.Methods The formulation of O-CMC multi-hemostatic Sponge was optimized by using central composite design-response surface methodology (CCD-RSM), in which the O-CMC, glutaraldehyde and thrombin was used as enzyme immobilization carrier, crosslink agent and coagulant, respectively.The crosslinked conditions of thrombin were studied by determined the enzymatic activity yield.Results The optimized concentrations of O-CMC, thrombin and glutaraldehyde were 2.49 %, 49.87 IU/mL, 0.49%, respectively.Conclusion O-CMC multi-hemostatic Sponge has the positive immobilization effect on thrombin.
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