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Objective: UroVysion FISH has been used for screening bladder cancer in western countries,but still limited in China.This non-invasive assay is also practical for detecting upper tract urothelial carcinoma.The present study evaluates the effectiveness of UroVysion and urine cytology in detecting upper tract urothelial carcinoma (UTUC) in 216 urine samples from 75 Chinese patients.