Atherosclerosis is the leading cause of death,both above and below age 65,in the United States and all Western countries.Its earliest prelesion events appear to be the transmural(across the wall)-pressure(ΔP)-driven advection of large molecules such as low-density lipoprotein(LDL)cholesterol from the blood into the inner wall layers across the monolayer of endothelial cells that tile the blood-wall interface.