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The mesosphere and thermosphere region is the unique connection between the Earth's atmosphere and the outer space.In this space-atmosphere-interaction region(SAIR),the natural upward extension of the atmosphere ultimately leads to interaction with space above 50 km altitude,and become entwined with the dynamic plasma.It is strongly impacted by both the activities originated from lower atmosphere and by the space weather.An objective with high priority for the upper atmosphere science community is to fully explore,understand and be able to predict it,which requires comprehensive measurements of the neutral atmosphere to complement the common observations of the plasma.Unfortunately such measurements are inherently difficult and also incomplete.