A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilament

来源 :第八届工业与应用数学国际大会 | 被引量 : 0次 | 上传用户：yuxjmail

【摘要】

：

　　The shape and function of an axon is dependent on its cytoskeleton,including microtubules,neurofilaments and actin.Neurofilaments accumulate abnormally in a

【作者】

：

XueChuan;

【机构】

：

Ohio State Univ.

【出处】

：

第八届工业与应用数学国际大会

【发表日期】

：

2015年期

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　　The shape and function of an axon is dependent on its cytoskeleton,including microtubules,neurofilaments and actin.Neurofilaments accumulate abnormally in axons in many neurological disorders.An early event of such accumulation is a striking radial segregation of microtubules and neurofilaments.This segregation phenomenon has been observed for over 30 years now,but the underlying mechanism is still poorly understood.I will present a stochastic multiscale model that explains these phenomena and generates testable predictions.

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A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilament

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