Bayesian optimal interval design for dose finding based on both efficacy and toxicity outcomes

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：wuyuwei1210

【摘要】

：

One of the main purposes of a phase dose-finding trial in oncology is to identify a tolerable dose with an indication of therapeutic benefit to administer to subjects in subsequent phase Ⅱ and Ⅲ trial

【作者】

：

Masataka Taguri Kentaro Takeda Satoshi Morita

【机构】

：

Department of Biostatistics,Yokohama City University,Yokohama 221-0056,Japan

【出处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

Bayesian adaptive design dose-finding interval design nonparametric method phase

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Bayesian optimal interval design for dose finding based on both efficacy and toxicity outcomes

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