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Inhibition of Rho-kinase displays vasodilation property although its effect on cardiac remodeling in heart against pressure overload and ischemia has not been fully elucidated.The present study was designed to examine the effect of fasudil,a Rho-kinase (ROCK) inhibitor,on myocardial remodeling and underlying mechanisms in pressure overload and myocardial infarction (MI) mice.Pressure overload was produced by constriction of the transverse aorta (TAC) for 3 weeks.