论文部分内容阅读
We studied whether serum fasting levels of active form of peptide YY (PYY), PYY(3-36), are associated with obesity and related phenotypes.Study population consisted of 428 patients with coronary artery disease and diagnosed type 2 diabetes and 440 patients with coronary artery disease but without evidence of diabetes from ARTEMIS-STUDY.The patients were recruited from the consecutive series of patients undergoing coronary angiography in the Oulu University Hospital.The patients without diabetes underwent a 2-hour oral glucose tolerance test.PYY(3-36) levels were analyzed by human PYY(3-36) specific radioimmunoassay.Result suggested that when PYY(3-36) tertiles were considered, high serum fasting PYY(3-36) concentration was associated with high body mass index, waist circumference, hemoglobin A 1 c, fasting blood glucose, leptin, triglyceride (p for all p-3d0.001), serum insulin (p=0.013) and with a low high-density lipoprotein cholesterol (p=0.004) concentrations in the analyses adjusted for age, sex and study group.The link high PYY(3-36)-high insulin level was evident in subjects with normal glucose tolerance (p<0.05).The prevalence of diabetes was 72%, 46% and 30% in the highest, medium and lowest PYY(3-36) tertile (p<0.001).The PYY(3-36) concentrations (after adjustment for age, sex and body mass index) were higher in type 2 diabetics compared to subjects with impaired fasting glucose, impaired glucose tolerance and normal glucose tolerance (p<0.001 for trend).In conclusion, fasting PYY(3-36) concentrations in type 2 diabetic subjects are high.Although high PYY(3-36) is strongly linked to obesity and associated insulin resistance, the relation between PYY(3-36) and type 2 diabetes is independent on body fatness.