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Objective:To investigate the clinical effect of multimodal ultrasound-guided subacromial bursa drug injection in the treatment of subacromial bursitis.Methods:From October 2017 to October 2018,80cases of simple subacromial bursitis were diagnosed in orthopedic department of our hospital because of shoulder pain and limited movement.By drawing lots,we were randomly divided into multimodal ultrasound group (n=40) and control group (n=40).Conventional ultrasound,Color Doppler,Ultrasound elastography and Ultrasonic panoramic imaging were used in multimodal ultrasound group and conventional anatomic localization was used in control group.And followed up for 3 months.VAS pain score and Constant-Murley (CMC) shoulder joint function score were used to evaluate the status of subacromial bursitis in the two groups before and after treatment.Results:Before treatment,there were no significant differences in VAS scores (8.05±0.78)points vs (8.16±0.88)points and CMC total scores (41.13±5.88)points vs (39.59±5.19) points between multimodal ultrasound group and control group.After treatment,the differences in VAS scores (1.58±0.13)points vs(4.28±1.8)points and CMC total scores (79.73±4.36) points vs (61.58±3.96)points between multimodal ultrasound group and control group were significant (P <0.05).The differences within the two groups before and after treatment were significant (P <0.05).Conclusion:Multimodal ultrasoundguided subacromial bursa injection is effective in the treatment of subacromial bursitis,the effect is better than the traditional anatomic localization of injection.