Objective: To assess the effect and safety of Wenxin Granule on Atrial Fibrillation.Method: We searched the electronic databases of CNKI (from 1995 to October 2010),PubMed (from 1966 to October 2010),EMBASE (from 1974 to October 2010) and Cochrane library (Issue 10,2010),manually retrieved relevant journals,papers of graduates and meetings by October 2010,chose randomized controlled trials of Wenxin Granule and performed Meta-analysis with RevMan 5.0.2 software.