【摘 要】
：
Multidrug resistance(MDR)was one of the major obstacles to the effective cancer chemotherapy.The mechanisms about MDR was mainly attributed to p-glycoprotein(Pgp)-reliable drug efflux pump and Bcl-2 p
【机 构】
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School of Pharmaceutical Sciences,and Fujian Provincial Key Laboratory of Innovative Drug Target Res
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Multidrug resistance(MDR)was one of the major obstacles to the effective cancer chemotherapy.The mechanisms about MDR was mainly attributed to p-glycoprotein(Pgp)-reliable drug efflux pump and Bcl-2 protein-mediated anti-apoptotic non-pump [1].Here,we combined the two molecular targets to design the intracellular co-delivery systems of DOX(anticancer drug)and NuBCP-9(Bcl-2-binding and converting peptide)[2] using the modified mesoporous silica nanoparticles with highly-branched PAMAM dendrimers for the effective MDR therapy.In the present study,the re-engineering MSN was characterized by dynamic light scattering,UV-vis,Fluorescence,NMR,nitrogen adsorption-desorption isotherm,and transmission electron microscopy measurements.
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