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Bone defect is a common clinical disease,regeneration and repair of the damaged hard tissue is still a huge challenge in the biomedical field.In recent years,rare earth ion doped apatite up-conversion luminescent nanomaterials (REAUC nps) have wide application prospects in tracing the situation of repair the damaged hard tissue,bioimaging,drug/gene delivery,and optical dynamic tumor treatment due to their unique physical and chemical properties.