缓激肽受体基因敲除对小鼠阿霉素性心肌损伤模型eNOS和iNOS表达的影响

来源 :第四届药物毒理学年会 | 被引量 : 0次 | 上传用户：beefshen

【摘要】

：

目的阿霉素(Doxorubicin,BOX),是一种高效广谱的抗肿瘤药物,然而剂量依赖性的心脏毒性使其应用受到限制。这可能和其可产生氧自由基(OFR)导致心肌氧化损伤有关。为观察缓激肽受体介导的NO信号通路在DOX致急性心肌损伤中的作用,本研究采用野生型和缓激肽(BK)受体双敲除(B132√-)小鼠模型观察了eNOS和iNOS在DO×性急性心肌损伤中的表达。

【作者】

：

谢克让苏素文郭会彩许彦芳张海林

【机构】

：

河北医科大学药理学教研室河北医科大学卫生毒理教研室,石家庄050017

【出处】

：

第四届药物毒理学年会

【发表日期】

：

2014年5期

【关键词】

：

阿霉素缓激肽心肌损伤 iNOS eNOS

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缓激肽受体基因敲除对小鼠阿霉素性心肌损伤模型eNOS和iNOS表达的影响

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