【摘 要】
：
目的 分析胰腺癌的临床病理学特征及其预后.方法 回顾性分析存储于生物芯片上海国家工程研究中心所属生物样本库2002年7月至2014年4月接受了手术治疗的804例胰腺癌患者临床病理资料,分析胰腺癌患者临床病理学特征与预后的相关性.结果 804例胰腺癌患者的平均年龄为59.6岁,男465例(57.8％),女302例(37.6％),不详37例(4.6％),男女比率为1.54∶1.有淋巴结转移255例(3
【机 构】
：
200065 同济大学医学院附属同济医院消化科 生物芯片上海国家工程研究中心
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
论文部分内容阅读
目的 分析胰腺癌的临床病理学特征及其预后.方法 回顾性分析存储于生物芯片上海国家工程研究中心所属生物样本库2002年7月至2014年4月接受了手术治疗的804例胰腺癌患者临床病理资料,分析胰腺癌患者临床病理学特征与预后的相关性.结果 804例胰腺癌患者的平均年龄为59.6岁,男465例(57.8％),女302例(37.6％),不详37例(4.6％),男女比率为1.54∶1.有淋巴结转移255例(30.7％),376例无淋巴结转移(45.2％).胰腺癌淋巴结转移与分化程度、局部浸润显著相关(P均＜0.05).有127例患者获得详细生存随访资料,胰腺癌的中位生存期为12个月.胰腺癌患者1、3、5年生存率分别为49.8％、33.1％、26.0％.Kaplan-Meier法分析显示,患者病理组织类型、分化程度、美国癌症联合会(AJCC)分期、淋巴结转移、临床分期(N分期)与患者生存预后密切相关(P均＜0.05).单因素COX回归模型显示,分化程度、AJCC分期、淋巴结转移、临床分期(N分期)是影响胰腺癌生存预后的危险因素(P均＜0.05).将上述不利因素引入多因素COX回归模型,并通过性别、年龄因素校正,结果提示肿瘤分化程度(P=0.007)是影响大肠癌生存预后的独立因子.结论 胰腺癌的生存预后差,分化程度是影响其生存的独立危险因素.
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目的 探讨胃肠道间质瘤患者的临床特点及其预后的危险因素.方法 回顾性分析生物芯片上海国家工程研究中心所属生物样本库(生物银行)所存储的2004年8月至2014年4月均接受了手术治疗的293例胃肠道间质瘤患者的临床表现,并对其中135例患者的生存状态进行了系统性分析.应用KaplanMeier法和log-rank检验对胃肠道间质瘤的生存期进行分析.结果 在293例接受了肝癌切除术的患者中,男170例