溃肠宁是导师甘爱萍教授在长期研究与治疗UC的基础上形成的有效经验方.该方具有健脾助运、清热燥湿、凉血解毒、收涩止痢、行气活血之功.前期研究显示，溃肠宁对UC患者有很好的治疗效果.本实验拟采用TNBS缓慢灌肠建立复发性UC动物模型，观察溃肠宁对UC大鼠结肠和血清IL-6、IL-10含量及结肠病理结构的影响，探讨溃肠宁治疗UC的细胞分子机制，为该方的临床运用提供科学依据.结语：1.中药溃肠宁治疗UC疗
目的观察费建平教授使用中西医结合治疗大肠湿热型溃疡性结肠炎的临床疗效.方法将符合纳入标准的患者随机分为治疗组和对照组,治疗组予美沙拉秦肠溶片口服,结合中成药口服、中药灌肠、针刺、耳穴等治疗；对照组单纯予美沙拉秦肠溶片口服,总疗程为八周,疗程结束后,对两组中医证候积分、中医证候疗效、肠镜积分、肠镜下粘膜疗效及临床综合疗效进行分析.结果疗程结束后,治疗组在临床综合疗效、中医证候疗效、肠镜积分、肠镜下粘
目的：观察溃结宁膏对大鼠血清及结肠组织IL-10及IL-12的影响，探讨溃结宁膏穴位贴敷治疗脾肾阳虚型大鼠溃疡性结肠炎(UC)的机理.方法：采用三硝基苯磺乙醇法制作UC大鼠模型，检测空白组、溃结模型组、溃结预防敷贴组、溃结敷贴治疗组、溃结对照敷贴组及溃结阳性对照组IL-10、IL-12含量变化，并进行统计学分析.结果：溃结预防敷贴组及溃结敷贴治疗组均能明显升高UC大鼠IL-10降低IL-12的水平
Backgroud: The capability of NK cells to mediate Fc-receptor dependent effector functions like ADCC largely contributes to the clinical application.However, few antibodies targeting leukemia cells are
The production of type Ⅰ interferon must be tightly regulated, and the aberrant production of this protein is harmful or even fatal to the host.The transcription factor IRF3 phosphorylation is a centr
Animals exploit different germline-encoded proteins with various domain structures to detect the signature molecules of pathogenic microbes.These molecules are known as pathogen-associated molecular p
Integrins are critical for migration and function of leukocytes in inflammation and autoimmune diseases.Integrin CD11b on DCs inhibits full T-cell activation and facilitates the development of periphe
Recently, assembly of inflammasome has been identified as a critical event to initiate inflammation.However, its role in bacterial killing remains unknown.The present study demonstrates that Pseudomon
Background: Ischemic preconditioning (IPC) exerts a protective effect in hepatic ischemia/reperfusion (I/R) injury.The exact mechanism of IPC action remains largely unknown.Recent studies suggest that
目的:课题组前期研究发现补体活化在急性肾盂肾炎的发病过程中对机体起到有害作用,但其机制尚不清楚.补体活化过程中产生的小片段C5a是重要的炎性介质,通过与广泛分布在各种免疫细胞/上皮细胞上的受体相互作用而发挥多种生物学效应.C5aR1和C5L2是C5a已知的两个受体,二者结构同源,但C5L2缺少G蛋白偶联结构域.本研究拟探讨C5a是否通过与C5aR1和/或C5L2相互作用从而影响急性肾盂肾炎的发生、