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  5. Effect of BDNF genetic polymorphisms on psychopathological traits associated with anorexia and bulim

Effect of BDNF genetic polymorphisms on psychopathological traits associated with anorexia and bulim

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：lingang89029
【摘 要】
：
Aim: The brain-derived neurotrophic factor (BDNF) gene has been shown to affect eating behavior.We aimed to investigate whether BDNF genetic variability may influence psycopathological traits in patie
【作 者】
：
Juan Antonio CARRILLO Carmen GAMERO Angustlas GARCIA-HERR(A)IZ Isalud FLORES Inmaculada GORDILLO Melchora MONGE Mercedes JIM(E)NEZ Raquel RODRIGUEZ-L(O)PEZ Guillermo GERVASINI 
【机 构】
：
Department of Medical & Surgical Therapeutics, Division of Clinical Pharmacology, Medical School, Un
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
anorexia nervosa bulimia nervosa brain-derived neurotrophic factor (BDNF) 
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Aim: The brain-derived neurotrophic factor (BDNF) gene has been shown to affect eating behavior.We aimed to investigate whether BDNF genetic variability may influence psycopathological traits in patients with eating disorders (ED).Methods: A totai of 120 unrelated female patients with anorexia or bulimia nervosa (AN, BN) and 125 healthy controls were genotyped for two common BDNF single nucleotide polymorphisms (SNP), Val66Met and C-270C, and several selected tag SNPs.Associated psychopathological characteristics were assessed by the EDI-2 and SCL-90R inventories.
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