Crystallization in Drug R&D Challenges: Wrong Solid Form and Particle Attributes · Tight drug development timeline · Limited availability of starting material
Outline Introduction An overview on crystal growth Morphology of crystals: prediction and modification Crystal networks: classification and formation kinetics C
Some Caveats "Those who have knowledge dont predict.Those who predict, dont have knowledge"-Lao Tzu, 6th century BC Chinese poet "Prediction is very difficult,e
Cocrystals · are crystals that contain two or more different molecular components · components are solids at room temperature · often rely on hydrogen-bonded
Key Questions · Can cocrystals form as a result of stresses encountered during pharmacautical processing and storage?· How to maintain a desired cocrystal for
Andrew Cassity Catherine Gardner Ernest Chow Mark Eddleston Erica Bithell Graeme Day Tomislav Friscic Andrew Trask Shyam Karki Bhavnital Patel Kreso Dejan-Bucar