【摘 要】
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Inheritance of 5-methyl cytosine modification of CpG DNA sequence is needed to maintain early developmental decisions in vertebrates (Wang et al.,2014).The
【机 构】
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北京航空航天大学,软件学院,北京100191教育部生物信息学重点实验室,周培源应用数学研究中心,清华大学,北京100084
【出 处】
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第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Inheritance of 5-methyl cytosine modification of CpG DNA sequence is needed to maintain early developmental decisions in vertebrates (Wang et al.,2014).The standard inheritance model treats CpGs as independent,with methylated CpGs maintained by efficient methylation of hemimethylated CpGs produced after DNA replications,and unmethylated CpGs maintained by an absence of de novo methylation.However,this standard model is inconsistent with many experimental observations.A model with dynamic collaboration between CpGs can provide strong error-tolerant somatic inheritance of both hypermethylated and hypomethylated states of a cluster of CpGs (Haerter et al.,2014).However,this model fail to reproduce experimental observations over a whole genome in which CpG island and low-density CpG regions are mixed.Here,we present a new model with collaboration between CpG sites,in which the correlation is varied with the distance between adjacent CpG sites.The model provide good agreement with the overall patterns of DNA methylation in a genome.Both model and experiment data predict that the dynamics of DNA methylation show strong correlation through the nucleosome.
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