Optimized heptapeptide A7R for enhanced tumor targeting nano-drug delivery

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：coolfish150

【摘要】

：

　　Tumor targeting ligands holds the promise of enhanced antitumor efficacy.Heptapeptide LA7R,identified by screening a mutated phage, was shown to bind specif

【作者】

：

ManYing;QingShen;CaoXie;XiaoliWei;JieGao;WeiyueLu;

【机构】

：

Department of Pharmaceutics, School of Pharmacy, Fudan University.Key Laboratory of Smart Drug Deliv

【出处】

：

2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会

【发表日期】

：

2015年期

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　　Tumor targeting ligands holds the promise of enhanced antitumor efficacy.Heptapeptide LA7R,identified by screening a mutated phage, was shown to bind specifically to neuropilin-1 (NRP-1) receptor and VEGFR2 receptor that were over-expressed on U87 glioma cells, glioma vasculogenic mimicry and tumor neovasculature.Therefore, LA7R conjugated liposomes transporting doxorubicin were supposed to be "systemic targeted drug delivery".

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Optimized heptapeptide A7R for enhanced tumor targeting nano-drug delivery

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