四(3_甲氧基_4_羟基苯基)卟啉金属配合物的微波合成及其化学模拟

来源 :中国化学会第四届卟啉与酞菁学术研讨会 | 被引量 : 0次 | 上传用户:knightxmu
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  羟基自由基(·OH)是人体内最主要的有毒氧自由基,易造成人体组织脂质过氧化、核酸断裂、蛋白质分解,并与机体的衰老、肿瘤、辐射损伤和细胞吞噬有关[36]。
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离子化法是制备水溶性卟啉的主要方法之一,通过卟啉中吡啶基、氨基质子化形成阳离子型水溶性卟啉;或经由磺化反应引入磺酸根、也可通过羧酸脂基水解的方法得到阴离子型水溶性卟啉;多种类型的功能性基团可以通过酰化、取代或配位等简单的反应引入到卟啉体系中,从而满足卟啉功能性结构设计要求,这对于卟啉化合物的生物活性研究有着积极的作用。