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  5. Computational Design of D-Peptides targeting TNF

Computational Design of D-Peptides targeting TNF

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：xxssdd55
【摘 要】
：
Background: The Tumor necrosis factor (TNF) is an established therapeutic target for rheumatoid arthritis and other autoimmune diseases.The 5 TNF antagonists available on market now are all protein th
【作 者】
：
杨为 张长胜 来鲁华 
【机 构】
：
北京大学化学与分子工程学院,分子动态与稳态国家重点实验室,北京,100871 北京大学-清华大学联
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
TNF protein design D-amino acid 
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　　Background: The Tumor necrosis factor (TNF) is an established therapeutic target for rheumatoid arthritis and other autoimmune diseases.The 5 TNF antagonists available on market now are all protein therapeutics.A major problem limiting development of protein therapeutics is their sensitivity to proteases and delivery challenges.D-Peptides are highly resistant to natural proteases because of the stereospecificity.
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