Curcumin-mediated photodynamic damages to Escherichiacoli

来源 :2015年中国生物医学工程联合学术年会 | 被引量 : 0次 | 上传用户：wmhgm

【摘要】

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【作者】

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Chuanshan Xu Yuan Jiang Pan Wang Hongwei Zhang Heyu Hua Albert Wingnang Leung

【机构】

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School of Chinese Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong,China

【出处】

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2015年中国生物医学工程联合学术年会

【发表日期】

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2015年11期

【关键词】

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Photodynamic inactivation curcumin light-emitting diodes Escherichiacoli

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　　Objective: The present study aims to investigate that LED light-activated curumin induced the damages of Escherichiacoli(E.coli).Materials and methods: E.coli was incubated with different concentrations of curcumin for 60 min and irradiated by blue light from a light-emitting diodes(LED)source.After photodynamic treatment,bacterial colony forming units(CFU)were investigated usingcolony formation assay.Membrane integrity was measured confocal laser scanning microscopy(CLSM)with PI staining.The ultrastructural morphology was observed using a transmission electron microscopy(TEM).Results: CFU assay showed that photodynamic treatment of curcuminsignificantly killed E.coli.TEM showed that cell membrane break and more vacuoles.CLSM showed more PI dye in E.colicellsafter photodynamic treatment of curcumin.Conclusion:Photodynamic treatment of curcumin damaged membrane permeability,resulting in death of E.colicells.

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Curcumin-mediated photodynamic damages to Escherichiacoli

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