Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMPR-IB on UHMWPE-Induced Bone Destruction

来源 :中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议 | 被引量 : 0次 | 上传用户:adamsqiu
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Objective Adenovirus expressing small interfering RNA(siRNA)-targeting BMPR-IB was locally administered into the air pouch of mice to improve bone resorption induced by ultrahigh molecular weight polyethylene (UHMWPE) particles.Method Air pouches were established on the back of BALB/c mice, followed by the surgical introduction of a section of calvaria from a syngeneic mouse donor.The bone-implanted pouches were stimulated with the UHMWPE suspension.
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