Site-specific chemical conjugation of proteins can enhance their therapeutic and diagnostic utility but has seldom been applied to CRISPR/Cas9,which is a ra
Tumor-associated carbohydrate antigens(TACAs)are regarded as important targets for vaccine development.Vaccines based on synthetic oligosaccharide antigens
Modified nucleotides,especially those related to epigenetic or epitranscriptomic functions,provide critical regulatory information beyond their sequence and
It has been a longstanding question in the field as to why OGT is required for dividing mammalian cells.In the past few years,my lab has been trying to addr
Bacterial surface polysaccharides are often structurally unique and immunologically active,have become attractive molecular targets in the development of an
Transfer RNA derived fragments(tRFs)are one class of small RNAs which have multiple functions in human beings,including regulation of viral replication,inhi