Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects

来源 :第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) | 被引量 : 0次 | 上传用户:iuxiaolove
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  There is increasing evidence of activities of chlorinated by-products of bisphenol A(BPA)on retinoic acid system.Their agonistic and antagonistic activities to human retinoid X receptor(RXR)were assessed by a two-hybrid yeast assay.Aqueous solutions of 1 mg/L BPA were chlorinated by sodium hypochlorite(NaClO).It showed that chlorination of BPA increased RXRβ antagonistic activity,while no agonistic activity was detected,showing chlorine might act as a toxic potentiator rather than a toxic deactivator in RXRβ disrupting effects.BPA and its byproducts including 2,2,6,6-tetrachlorobisphenol A(TCBPA)and 2,4,6-trichlorophenol(TCP)were quantitatively determined by gas chromatography/mass spectrometry(GC/MS).BPA rapidly degraded.With the increasing of ICC and reaction time,concentration of formed TCBPA increased initially then decreased,while concentration of formed TCP increased stably.Using the toxic equivalent(TEQ)approach,the main contributors should be mono-,di-and tri-chlorobisphenol A at initial chlorine concentration(ICC)of 1 mg/L.At ICC of 2 and 5 mg/L,the main contributors were TCBPA and TCP,being 57.7%-70.7%and 45.3%-59.4%.Molecular docking showed BPA chlorination by-products might have the same mode of action with BPA,forming hydrogen bond and pi-pi interaction with their OH group or hydrophobic ring.
其他文献
  PRMT5 is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate
会议
  Introduction: Psoriasis is a refractory skin disorder,and usually requires a lifetime control.Traditional Chinese medicine(TCM)is effective and safe for thi
  In an effort to develop a practical method for the synthesis of optically pure 2,2,2-trifluoro-1-phenylethanol,we found that the carbonyl reductase(SSCR)fro
  SIRT2,which is a NAD+(nicotinamide adenine dinucleotide)dependent deacetylase,has been demonstrated to play an important role in the occurrence and developm
会议
The high morbidity and mortality of cancer make it one of the leading causes of global death,thus it is an urgent need to develop effective drugs for cancer the
会议
  N-acetyl glutamate kinase(NAGK)is a key enzyme in the synthesis of L-arginine,and L-arginine-sensitive NAGK typically has hexameric architecture.Defining th
Based on the structural features of fluometuron,an immunizing hapten was synthesized and conjugated to bovine serum albumin as an immunogen to prepare a polyclo
会议
  β-Mannanase has been widely used in industries such as food and feed processing and thus has been a target enzyme for biotechnological development.In this
  The resistance of feed enzymes against proteases is crucial in livestock farming.In this study,the trypsin resistance of aflatoxin-detoxifizyme(ADTZ)is impr
  BmP02,a peptide with 28 residues from the Chinese scorpion ButhusmartensiKarsch,hasbeen reported to inhibit the transient outward potassium currents(Ito??)i