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Kaempferol with hepatoprotective activity is a biologically active component that present in various foods.The present study is aimed to investigate the mechanism behind the effect of kaempferol against alcoholic liver disease(ALD)in mice.The experimental ALD mice model was developed and treated with different doses of kaempferol,in parallel silybin,diallyldisulfide and N-acetyl-cysteine were conducted as positive control drugs.