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MicrosoftInternet Explorer 402 Document Not Specified 7.8 磅 Normal0 Introduction Hypothalamic hamartomas may be associated with gelastic seizures and a generalized epileptic encephalopathy,with cognitive and behavior decline.Resection was long regarded as too hazardous and unlikely to benefit seizure control.Materials and methods We reviewed our experience of surgical treatment for hypothalamic hamartomas with epileptic seizures.Lateral pterional,midline frontal through the transcallosal interforniceal approaches were compared.Mortality,morbidity,and efficacy of these neurosurgery procedures were considered.Our experience of pediatric neurosurgery is based on a retrospective analysis which enrolled 31 patients with HH and associated severe epilepsy between August 2007 and August 2014.