【摘 要】
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Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.Parthenolide (PN) has been proved to elicit a wide range of biological activities
【机 构】
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Department of Neurology,Second Hospital of Hebei Medical University
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Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment.Parthenolide (PN) has been proved to elicit a wide range of biological activities through its anti-inlammatory action in the treatment of migraine,arthritis,and atherosclerosis.To decide whether this efect applies to ischemic injury in brain,we therefore investigate the potential neuroprotective role of PN and the underlying mechanisms.Male Sprague-Dawley rats were randomly divided into Saline,Vehicle,and PN groups and a permanent middle cerebral artery occlusion (MCAO) model was used.
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