Tie self-assembly of amphiphilic copolymers yields nanostructures with a polar core and a hydrophobic shell in non-aqueous solvents,which is commonly referred to as reverse micelles (RMs) to differentiate them from the micellar aggregates formed in aqueous media.However,the application of RMs in drug delivery is rather rare.The RMs could transfer protein into the oil phase,while oil phases can form a continuum with the lipid barriers in the body,such as cell membranes and skin lipids [1].We and Leroux et al.reported the construction of RMs based on linear and star-shaped alkylated poly(glycerol methacrylate)s (PGOHMAs) for peptide and protein delivery [2].But,their drug loading ability is limited.