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Aim The reason why the majority of chronic hepatitis B (CHB) patients do not respond to conventional interferon α (IFNα) or pegylated interferon (Peg-IFN) treatment has not been formally demonstrated.The aim of this study was to investigate the association between single nucleotide polymorphisms (SNPs) and response to IFNα or Peg-IFN therapy in Chinese patients with CHB.