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Background Coronary atherosclerotic heart disease (CAD) is an important prognostic factor in patients with systemic lupus erythematosus (SLE).Most studies on lupus premature coronary heart disease failed to take the gold standardcoronary angiography (CAG) to confirm the diagnosis of CAD,it is difficult to avoid including coronary arteritis,arterial thrombosis and myocardial lesions.This study aimed to analysis the characteristics of traditional risk factors and coronary artery disease in female systemic lupus erythematosus (SLE) patients with premature coronary atherosclerotic heart disease (CAD) whose diagnosis was confirmed by CAG.