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  5. Protection by pitavastatin from doxorubicin-induced acute cardiotoxicity through suppression of oxid

Protection by pitavastatin from doxorubicin-induced acute cardiotoxicity through suppression of oxid

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：table
【摘 要】
：
Aim: Doxorubicin (DOX) is an effective chemotherapeutic drug.However, its clinical application may be hampered by dose-dependent cardiotoxicity.The mechanisms of DOX-induced cardiotoxicity are not ful
【作 者】
：
Yan-fei XIN Bin HAN Guo-liang ZHOU Zhen-qiang YOU Li-qiang GU Hai-yan GAO Sheng ZHANG Jian YU Yao-xian XUAN 
【机 构】
：
Center of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
doxorubicin cardiotoxicity pitavastatin oxidative stress 
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Aim: Doxorubicin (DOX) is an effective chemotherapeutic drug.However, its clinical application may be hampered by dose-dependent cardiotoxicity.The mechanisms of DOX-induced cardiotoxicity are not fully understood, but DOXrelative cardiotoxicity induced by other than those mediating their anticancer effectiveness.In the present study, we use a rat model to test whether the pitavastatin (PTT) can exert protective effects against DOX-induced cardiotoxicity.
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