Deficiency in homologous recombination repair(HRR)is frequently associated with hormone-responsive cancers,especially the epithelial ovarian cancer(EOC)which shows defects of HRR in up to half of case
Aerolysin-like proteins(ALPs)are aerolysin domain containing family of pore-forming proteins.They widely distributed in bacteria,fungi,plants and animals.
Although most natural proteins are composed exclusively of L-configuration amino acids,more and more emerging evidences showed that D-amino acids play crucial roles in sustaining the functions of prot
Studies have revealed that snake venoms from identical species in different regions differ in composition,toxicity and activity.This geographical venom variation might be caused by ontogeny,geographic
Regulation of endothelial cell adherent junctions is important to pathophysiological processes,in which vascular integrity is disrupted such as during tumor angiogenesis and chronic inflammatory condi
The Adaptive lymphocytes express a panel of activating and inhibitory immunoreceptors on their cell surface.Phospholipids are the major components of cell membranes,but they have functional roles beyo
The Rag/Gtr GTPases serve as a central module in the nutrient-sensing signaling network upstream of TORC1.In human,the nutrient-activated Rag heterodimer binds to mTORC1 to promote its recruitment to