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  5. Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular car

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular car

来源 :2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议 | 被引量 : 0次 | 上传用户：shulang198851
【摘 要】
：
Hepatocellular carcinoma (HCC) is a highly aggressive and lethal neoplasm with extremely poor prognosis.The aim of this study is to explore the anti-HCC activity of icaritin, and to mainly focus on th
【作 者】
：
Min-Bin Chen Xiao-Yang Wu Pei-Hua Lu 
【机 构】
：
Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, 9
【出 处】
：
2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议
【发表日期】
：
2015年1期
【关键词】
：
Hepatocellular carcinoma icaritin sphingosine kinase 1 and ceramide 
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　　Hepatocellular carcinoma (HCC) is a highly aggressive and lethal neoplasm with extremely poor prognosis.The aim of this study is to explore the anti-HCC activity of icaritin, and to mainly focus on the underlying mechanisms.We showed that icaritin is cytotoxic and pro-apoptotic against established (KYN-2, HepG2, and Huh-7lines) and primary human HCC cells.
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