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Blast crisis (BC)is highly refractory to therapy and has a poor prognosis.To determine the efficacy of TKIs-Ⅱ com bined with allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CML BC,we present four consecutive,recent cases of CML BC in which TKIs-Ⅱ were used before or after allo-HSCT.