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Objective:Toestablish zebrafish brain hemorrhage and heart hemorrhage modelsrespectively,and analyse whether the models are in common with the clinical syndrome of failureof the spleen to control blood.Method : In the first experiment,60 AB strain wild type zebrafisheswererandomly divided into normal group and model group.Thenormal group wasfeeded regularly,while the model group was treated with 50 μm simvastatin for 24h.The second experiment: ① The melanin allele mutated Albino strain zebrafishes were divided intonormal group(feeded regularly)and model group(treated with 50 μm simvastatin for 30min).