Preparation and Characterization of 1O-Hydroxycamptothecin Loaded Nanostructured Lipid Carriers

来源 :首届亚洲药物制剂科学研讨会(1st Asian Pharmaceutical Science and Technolog | 被引量 : 0次 | 上传用户:fancylhs
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Purpose Two types of 10-hydroxycamptothecin (10-HCPT) loaded nanostructured lipid careers (NLC-F 68 and NLC-Brij 35) intended for use as the altemative formulation of 10-HCPT for parenteral administration, were prepared.Methods 10-Hydroxycamptothecin (10-HCPT) loaded nanostructured lipid carriers were prepared using an emulsification-ultrasonication method and fully characterized from physicochemical and in vitro release standpoint.Results The particle size was 108 nm and 126 nm for NLC-F 68 and NLC-Brij 35, respectively.Zeta potential of two type NLCs were -28.5 mV and-32.1 mV.The incorporated efficiency both was more than 85%.It is observed that NLCs are homogeneous and spherical in shape by transmission electron microscopy.Differential scanning calorimetry analysis showed that 10-HCPT was dispersed within NLC in an amorphous state.The combination of trehalose and mannitol as cryoprotectants was most suitable for HCPT-NLC lyophilisation.The in vitro release behavior for two types of NLC was similar and displayed biphasic drug release pattem with burst release at the initial stage and prolonged release afterwards.Conclusion These results suggested that NLC could be exploited as a carrier with high incorporation efficiency and controlled release for 10-HCPT, and that NLC may serve as the alternative delivery system for parenteral administration of 10-HCPT.
其他文献
Purpose: Delivery of ciprofloxacin to alveolar macrophages arid antibacterial effect against intracellular parasites following pulmonary administration of ciprofloxacin incorporated into liposomes wer
Purpose:To investigate the effects of several absorption enhancers on the intranasal absorption of 2,3,5,6-tetramethylpyrazine phosphate (TMPP).Methods: An in situ nasal perfusion technique was used.R
New granulation technique using a spouted bed type binderless granulator and a jet mill to make the applicable PLGA nano-composite granules as DPI was examined.In the method, the PLGA nano-composite g
Purpose: Microparticulate delivery systems designed for the nasal administration of the anticancer drug, methotrexate, were prepared.Methods: MTX/chitosan complex microspheres were prepared by ionic c
Purpose: We tried to develop a formulation for local anesthetic with quicker onset.These formulations would be applied in laser-assisted surgery.Methods: The hot pre-emulsion is then processed in a te
会议
Purpose: To study in vitro transdermal permeability of amlodipine base (AM), amlodipine besilate (AM-B), amlodipine adipate (AM-A), amlodipine oxalate (AM-O) and amlodipine maleate (AM-M) from the EI
Purpose: The aim of the study was to compare the entrapment efficiency of 5-aminolevulinic acid (ALA) between encapsulated in liposomes and ethosomes.The images of confocal laser scanning microscopy (
Purpose To determine the formulation composition of a transdermal drug delivery system of indomethacin,MASCOS 10 pressure sensitive adhesive was used to prepare a drug-in-adhesive type patch containin
The aim of this study was to develop a microporous film for cellulose acetate (CA).A water-soluble polymer poly(ethylene glycol) (PEG) was used as a pore-forming agent to create micropores on CA films
Purpose: Optimized preparation of insulin-lauryl sulfate complex loaded poly (lactide-co-glycolide) nanoparticles; Methods: The complex nanoparticles were prepared by a modified emulsion solvent diffu
会议