【摘 要】
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Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties.However, the anti-inflammatory effects of CEP on
【机 构】
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Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University,Changch
【出 处】
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中国畜牧兽医学会家畜内科学会2014年学术研讨会
论文部分内容阅读
Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties.However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be elucidated.The purpose of the present study was to investigate the effects of CEP on LPS-induced mouse mastiffs.The mouse model of mastitis was induced by inoculation of LPS through the canals of the mammary gland.CEP was administered intraperitoneally at 1 h before and 12 h after induction of LPS.The results show that CEP significantly attenuates the infiltration of neutrophils, suppresses myeloperoxidase activity, and reduces the levels of TNF-α, IL-1 β, and IL-6 in LPS-induced mouse mastitis.Furthermore, CEP inhibited the phosphorylation of NF-κB p65 subunit and the degradation of its inhibitor IκBα.All the results suggest that CEP exerts potent anti-inflammatory effects on LPS-induced mouse mastitis.Accordingly, CEP might be a potential therapeutic agent for mastitis.
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