ZFX modulates the growth and Imatinib sensitivity of CD34+ chronic myeloid leukemia cells

来源 :2014天津国际干细胞论坛 | 被引量 : 0次 | 上传用户：LUOJIAJUN32

【摘要】

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【作者】

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Xiuyan Zhang Lun Xiao Wenjuan Ma Lili Sun Yun Zhao

【机构】

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Cyrus Tang Hematology Center,Soochow University,199 Ren'ai Road,Suzhou,China,215123

【出处】

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2014天津国际干细胞论坛

【发表日期】

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2014年3期

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ZFX (Zinc finger protein,X-linked) is a key regulator of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs).A recent report has demonstrated that Zfx is required for Notch intracellular domain (NotchlC) induced acute T-cell leukemia and MLL-AF9 induced myeloid leukemia in mice models.However,the expression and the role of ZFX in human leukemia (e.g.chronic myeloid leukemia,CML) havent been addressed yet.

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ZFX modulates the growth and Imatinib sensitivity of CD34+ chronic myeloid leukemia cells

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