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Objective:Renin-angiotension system is known to induce the development of atrial fibrillation through atrial structural and electrical remodeling.small conductance calcium-activated potassium channels(SK channels)are close association with development and progression of atrial fibrillation.SK2 is the main subunits of SK channels.However,the effect of Angiotensin Ⅱ on SK channels remain unknown.