Functional biomaterials are scaffolding materials incorporated with biologically active molecules or cells that could greatly promote tissue regeneration.Among the biomaterials, collagen has been widely used because it is the most abundant protein in the body and has suitable biocompatibility with many current applications.We have developed collagen scaffolds with collagen binding growth factors or stem cell capturing collagens and they can effectively promote tissue regeneration in varies tissues as shown in several animal models.Tissue regeneration is a complex process, involving tissue reconstruction, recreation of functional vascular network as well as recovery of the tissue functions.The collaborative effects of multiple growth factors will be considered in the future to design functional collagen materials for more effective tissues regeneration.The ultimate goal of this work is to develop medical device products from these functional biomaterials to reconstruct damaged human tissues or organs.