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Purpose:To evaluate the value of T1mapping and the extent of late gadolinium enhancement(LGE)in hypertrophic cardiomyopathy(HCM).methods:50 patients(male 26,female 24,mean age 48.3±19.3y)were included in this retrospective study,they were twenty normal(group1)and thirty cases of HCM(group2).Cardiac magnetic resonance was performed on a 3.0-T MR scanner(Inginia,Philips Healthcare)with 32-channel body surface coil and ECG gating.LGE imaging was performed in the whole heart coverage of short axis 12 min after administration of gadolinium.A steady-state free precession,single breath-hold Modified Look-Locker Inversion Recovery(MOLLI)sequence was used for T1 mapping,performed in short-axis before and 15 min after contrast administration.T1 native and post of myocardium and blood pool were measured in SA slices,and ECV was calculated.The extent of LGE was scored as the sum of LGE-positive segments in left ventricle 17-segment model.The left ventricle wall thickness(LVWT)was decided by the thickest myocardium in the cine image at end-diastole.Results:LGE was present in 31 patients(62%)and detected in 3.96±2.98 segments on average.There was significant difference among myocardial T1native and T1post,ECV,LVWT,ejection fraction and LGE score between the two groups.T1 native,ECV and LGE score have relative higher potency in differentiating diseased myocardium with sensitivity and specificity of 89.3%,78.6%,82.1%and 55.6%,50%,100%respectively.In group 2,there was relative high correlation between LGE score and T1 native,LGE score and LVWT,LVWT and T1 native with the correlative index was 0.309,0.420,0.594 respectively.Conclusion:T1 native,ECV and the LGE score provide indexes with higher diagnostic sensitivity and specificity for the diagnosis of hypertrophic cardiomyopathy,and the total segments of LGE should be treated as a better risk marker compared to the presence of LGE.