【摘 要】
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Objective To investigate the mutation of mitochondrial DNA and activity of respiratory chain complex in Chinese patients with MELAS.Methods 25 patients with MELAS diagnosed by clinical and pathologica
【机 构】
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Department of Neurology, Huashan Hospital, Fudan University
【出 处】
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The 12th Annual Asian and Oceanian Myology Center (AOMC)Scie
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Objective To investigate the mutation of mitochondrial DNA and activity of respiratory chain complex in Chinese patients with MELAS.Methods 25 patients with MELAS diagnosed by clinical and pathological features were included.Mitochondrion was isolated using differential centrifugation from muscle samples of 25 MELAS patients and 28 normal controls.The activities of respiratory chain complexes Ⅰ-Ⅴ and citrate synthase were detected by colorimetric assay, and the normal ranges of CI/CS, CⅡ / CS, CⅢ / CS,CⅣ / CS, CⅤ / CS for reference were determined.
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