目的观察实验狗序贯式体外反搏（ＥＣＰ）时肝总动脉和肠系膜上静脉血流量的变化，以探讨ＥＣＰ治疗病毒性肝炎的机理．方法狗１５只，分为ＥＣＰ组１２只，对照组３只．观察ＥＣＰ前、ＥＣＰ３０ｍｉｎ，６０ｍｉｎ和停止ＥＣＰ后３０ｍｉｎ肝总动脉、肠系膜上静脉血流量的变化．对照组狗不使用ＥＣＰ，但观察记录的时间与ＥＣＰ组相同．结果ＥＣＰ组狗在ＥＣＰ３０ｍｉｎ时主动脉收缩压和舒张压均升高，以舒张压升高为明显．于ＥＣＰ６０ｍｉｎ时，主动脉收缩压和舒张压较前下降，以收缩压下降明显（Ｐ＜００１）．在１０只狗身上观察到ＥＣＰ３０ｍｉｎ、６０ｍｉｎ时收缩期和舒张期肝总动脉的血流量比ＥＣＰ前平均增加分别为１４９％和２７０％．其中以舒张期肝总动脉血流量的增加更为显著，ＥＣＰ３０ｍｉｎ为２２５％，ＥＣＰ６０ｍｉｎ为４３８％．结论ＥＣＰ能有效增加肝动脉的血流量，改善肝脏的微循环，促进病变肝细胞的恢复 Objective To observe the changes of blood flow in the common hepatic artery and superior mesenteric vein during the ECP in experimental dogs to investigate the mechanism of ECP in treating viral hepatitis. Methods Fifteen dogs were divided into ECP group (n = 12) and control group (n = 3). The changes of hepatic and superior mesenteric vein blood flow were observed before ECP, ECP 30min, 60min and 30min after stopping ECP. The control group did not use ECP, but the observation time was the same as for the ECP group. Results In ECP group, the aortic systolic and diastolic blood pressures increased at ECP30min, and the diastolic blood pressure increased significantly. At E60, the systolic and diastolic pressures of the aorta decreased compared with those before, and the systolic blood pressure decreased significantly (P <001). ECP was observed in 10 dogs for 30 min. The systolic and diastolic hepatic artery blood flow increased by 14.9% and 27.0%, respectively, before ECP at 60 min. Among them, the diastolic hepatic artery blood flow increased more significantly, ECP30min was 225%, ECP60min was 438%. Conclusion ECP can effectively increase the hepatic artery blood flow, improve the microcirculation of the liver and promote the recovery of diseased hepatocytes