Drug release from porous silica particles coated with polyelectrolyte multilayers for chorioretinal

来源 :第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会 | 被引量 : 0次 | 上传用户:homemoons
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Purpose Ketorolac tromethamine (KT), one of nonsteroidal anti-inflammatory drugs (NSAIDs), is used to treat ocular inflammatory diseases.However, its narrow therapeutic window and short vitreous half-life limit its intraocular application.We have shown that adsorption loading of KT into porous silica (pSiO2) particles can provide a 2-week release in rabbit vitreous.However, KT release from pSiO2 was still fast and couldnt last for a Iong time.
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