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It is well established that myocardial hypoxic preconditioning may provide cardioprotection in hypoxia reperfusion (H/R) injury (for a review, see (1).However, young and old hearts differ in myocardial structure and endogenous cardioprotective mechanisms, and the myocardium of elderly individuals is more sensitive than that of the young to H/R injury.Animal studies have also shown older hearts to be less responsive to pre-conditioning.