【摘 要】
：
目的 比较研究三种强心药地高辛、哇巴因和米力农对小鼠吗啡戒断症状以及对小鼠自主活动的影响,探讨其可能的作用机制.方法 采用剂量递增法建立小鼠吗啡依赖模型,最后一次吗啡注射4h后,给予受试药或等体积的溶媒,lh后纳络酮催促戒断,记录30 min内的跳跃数和体重减少值.通过小动物自主活动记录仪评价三种强心药对小鼠自主活动的影响.结果 较大剂量地高辛(1.0和2.5mg·kg-,ig)既能显著性地减轻吗
【机 构】
：
郑州大学药学院临床药学系,河南郑州 450001;兰州大学第二医院药剂科,甘肃兰州 730030
【出 处】
：
第十五届中国神经精神药理学学术会议
论文部分内容阅读
目的 比较研究三种强心药地高辛、哇巴因和米力农对小鼠吗啡戒断症状以及对小鼠自主活动的影响,探讨其可能的作用机制.方法 采用剂量递增法建立小鼠吗啡依赖模型,最后一次吗啡注射4h后,给予受试药或等体积的溶媒,lh后纳络酮催促戒断,记录30 min内的跳跃数和体重减少值.通过小动物自主活动记录仪评价三种强心药对小鼠自主活动的影响.结果 较大剂量地高辛(1.0和2.5mg·kg-,ig)既能显著性地减轻吗啡依赖小鼠戒断后的腹泻症状,同时又能明显抑制小鼠戒断后的跳跃行为,该剂量也会抑制正常小鼠的自主活动；较小剂量地高辛(0.1和0.25 nmg·kg-1,ig)只能著性地减轻吗啡依赖小鼠戒断后的腹泻症状但对小鼠戒断后的跳跃行为没有显著性影响,该剂量对正常小鼠自主活动也没有明显影响.哇巴因(0.16 ～0.64 mg·kg-1,ip)和米力农(2.0～8.0 mg·kg-1,ip)均能明显减轻吗啡依赖小鼠戒断后的腹泻症状但对小鼠戒断后的跳跃行为均没有显著性影响,也不会影响正常小鼠的自主活动.结论 与哇巴因和米力农相比较,地高辛用于消除或减弱吗啡戒断症状更有潜力,地高辛强心作用和中枢抑制机制是其抑制吗啡戒断症状重要机制.
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