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Protein expression level of CT37 was analyzed by immunohistochemistry in the normal hepatic cell line HL7702, four HC cell lines (QGY7701, SMMC7721,Be17404 and HepG2), a normal hepatic tissue and 30 cases of HC tissues.CT37 protein expression was found in the HC cell line QGY7701 and 26.67％ (8/30) of HC tissues, but absent in other HC cell lines, the normal hepatic cell line HL7702 as well as the normal normal hepatic tissue.Some of HC tissues presented stronger immunostaining intensity and majority showed the heterogeneity of protein distribution.