【摘 要】
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In this research,we investigated striatal neurogenesis in 3,6,12 and 18-month old rats after cerebral ischemic injury.All rats were subjected to a 20 min middle cerebral artery occlusion (MCAO),given
【机 构】
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Department of Pathophysiology, Medical College, Fudan University, Shanghai 200032
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
In this research,we investigated striatal neurogenesis in 3,6,12 and 18-month old rats after cerebral ischemic injury.All rats were subjected to a 20 min middle cerebral artery occlusion (MCAO),given 5-bromodeoxyuridine (BrdU,30 mg/kg,i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO.Neurogenesis was assessed with double immunohistochemical/immunofluorescence labeling of BrdU and doublecortin (DCX),microtubule-associated protein 2 (MAP-2),or 67 kDa glutamic acid decarboxylase (GAD67).In 6,12,and 18-month old rats,the numbers of nestin+,BrdU+-DCX+ (a marker of newbom neuronal progenitors/immature neuron),BrdU+-MAP-2+ (a marker of newbom mature neuron),and BrdU+-GAD67+ (a marker of newborn GABAergic neuron) cells decreased dramatically in the ipsilateral striatum to MCAO compared with that in 3-month old rats.The results indicated that stroke-induced striatal neurogenesis still existed in aging rats.However,the capacity of neurogenesis in older rats was considerably lower than that in young adults.
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